49ers 2025 Opponents Meaning. The san francisco 49ers' week 17 loss to the detroit lions officially locked the team into last place in the nfc west, regardless of the outcome of their week 18 matchup against the. Dallas and indianapolis will both kick.
49ers beat cardinals cowboys lose to commanders colts lose to jaguars. 12/24/24 12:53 am usatoday ninerswire.